The engine and two carriages of the Janta Express, which travels between Dehradun and Varanasi, went off the rails near Bachhrawan village.
Several dozen people were also injured in the accident, officials said.
Villagers, police and railway guards are trying to rescue passengers trapped in the carriages.
Images from the scene show mangled carriages lying beside the track.
The state's junior railway minister Manoj Sinha said an inquiry has been ordered to find out what caused the accident.
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